(Download) "Potato Disc Tumor Induction Assay: A Multiple Mode of Drug Action Assay." by Phytomedicine: International Journal of Phytotherapy & Phytopharmacology * Book PDF Kindle ePub Free

April 21, 2021

eBook details

Title: Potato Disc Tumor Induction Assay: A Multiple Mode of Drug Action Assay.
Author : Phytomedicine: International Journal of Phytotherapy & Phytopharmacology
Release Date : January 01, 2003
Genre: Life Sciences,Books,Science & Nature,
Pages : * pages
Size : 195 KB

Description

Summary The study reported herein utilized the Agrobacterium tumefaciens-induced potato disc tumor assay. The objective was to verify the detection of antineoplastic activity in the potato disc tumor induction assay, regardless of the mode of antineoplastic drug action. Camptothecin, paclitaxel, podophyllin, vinblastine and vincristine were tested, each with a different mode of action. All drugs tested inhibited tumor induction. The order of activity was: camptothecin paclitaxel = vinblastine podophyllin = vincristine. No effect on the viability of the bacterium was detected. The A. tumefaciens-induced potato disc tumor assay was an effective indicator of antitumor activity regardless of the mechanism of drug action. Thus, this assay would be acceptable as a primary general screen for antineoplastic activity of various crude extracts, as well as for purified fractions, regardless of mode of inhibitory action on tumor formation.